July 19, 2019 | | Post a Comment

first_imgReviewed by James Ives, M.Psych. (Editor)Nov 28 2018Using light-sensitive proteins, researchers study the brain’s reward memory responseIn new pre-clinical research, scientists at the University of Maryland School of Medicine (UMSOM), led by Scott Thompson, PhD, Professor of Physiology, have identified changes in brain activity linked to the pleasure and reward system.The research, published in the journal, Nature, provides news insights into how the brain processes rewards, and advances our understanding of addiction and depression. The research, which was conducted by Tara LeGates, Ph.D., a Research Associate in the Department of Physiology, discovered that the strength of signals between two brain regions, the hippocampus and the nucleus accumbens, is critical for processing information related to a rewarding stimulus, such as its location.”These two parts of the brain are known to be important in processing rewarding experiences,” said Dr. Thompson.” The communication between these regions is stronger in addiction, although the mechanisms underlying this were unknown. We also suspected that opposite changes in the strength of this communication would occur in depression. A weakening of their connections could explain the defect in reward processing that causes the symptom of anhedonia in depressed patients.” Anhedonia is the inability to enjoy normally pleasurable experiences, such as food, being with friends or family, and sex.This research uncovered a key circuit in the brain of mice that is important for goal-directed behaviors and shows that the strength of the signals in this circuit are changeable, a process referred to as plasticity. Reward circuits and the molecular components that underlie their plasticity represent new targets for development of treatments for disorders like addiction and depression.Using Light-Sensitive ProteinsRelated StoriesAn active brain and body associated with reduced risk of dementiaResearchers measure EEG-based brain responses for non-speech and speech sounds in childrenNeural pathways explain the relationship between imagination and willingness to helpTo activate or inhibit this connection, researchers used special light-sensitive proteins introduced into specific neurons in the brains of the mice. In mice with the light-sensitive protein that stimulated the neurons, just four seconds of light exposure not only activated this hippocampus-to-nucleus accumbens pathway while the light was on but persistently reinforced the strength of the signals along this pathway, creating an artificial reward memory.A day later, the mice returned to the place where the artificial memory was created, even though they never experienced an actual reward there. Researchers then used light to silence the same pathway in mice with the light-sensitive protein that inhibited the neurons and found that this pathway is required for associating a reward with its location. The mice no longer showed a preference for the place where they had interacted with another mouse.The researchers also examined this circuit in depressed mice. This pathway could not be enhanced using the stimulating light-sensitive protein. After receiving anti-depressant medication, the researchers could enhance this pathway using the light-sensitive protein and create artificial reward memories in the mice.This work was funded by the National Institutes of Health, the Whitehall Foundation, and the Brain & Behavior Research Foundation (NARSAD Young Investigator Grant).”These exciting results bring us closer to understanding what goes wrong in the brains of clinically depressed patients,” said UMSOM Dean E. Albert Reece, MD, PhD, MBA, who is also the Executive Vice President for Medical Affairs, University of Maryland, and the John Z. and Akiko K. Bowers Distinguished Professor. Source:http://www.medschool.umaryland.edu/news/2018/UMSOM-Researchers-Discover-Clues-to-Brain-Changes-in-Depression.htmllast_img read more

July 18, 2019 | | Post a Comment

first_img Source:https://www.vetmeduni.ac.at/en/infoservice/press-releases/press-releases-2019/new-therapy-for-aggressive-blood-cancer-discovered/ Reviewed by Alina Shrourou, B.Sc. (Editor)Feb 13 2019Acute myeloid leukemia (AML) is the most common form of acute leukemia. It is characterized by an increase of malignant myeloid progenitor cells at the expense of mature blood cells. Only twenty-five percent of all AML patients survive five years beyond the initial diagnosis. Therefore there is an urgent need to deepen the knowledge about this form of blood cancer and to develop new therapeutic approaches.A study carried out by researchers at the Ludwig Boltzmann Institute for Cancer Research, the Vetmeduni Vienna and the Medical University Vienna has now identified a possible approach for the treatment of AML patients, which carry a mutated, oncogenic isoform of the protein C/EBPα. According to the results published in Leukemia, the interaction of the mutated protein with an epigenetic regulator, the so-called MLL1 complex, represents a specific vulnerability of AML cells with CEBPA mutations. If the MLL1 complex was functionally inhibited, AML cells underwent cell death. Via targeted inhibition of MLL1, the cancer-associated block in normal blood cell maturation could potentially be released in affected AML patients.Focusing on the malignant isoform of an important factor in blood developmentThe transcription factor CCAAT/enhancer binding protein alpha C/EBPα, is an important regulator of blood development, as it controls critical steps in the maturation of blood cells. However, in ten to fifteen percent of all AML patients, the CEBPA gene harbors mutations that prevent the formation of the correct protein isoform.”In AML patients, most mutations occur in the N-terminal part of the CEBPA gene. This leads to the production of a shortened C/EBPα protein, the isoform p30, which is responsible for keeping cells in an immature state and can thus trigger leukemia”, explains Luisa Schmidt, the first author of the study, whose work was funded by a fellowship from the Austrian Academy of Sciences (DOC).The oncogenic protein variant C/EBPα p30, which is over-produced as a result of the mutation, makes use of epigenetic mechanisms to control gene expression in leukemia cells.Oncogenic protein variant requires functional epigenetic regulator complexIt is known that epigenetic processes can control the expression of genes. It has also been shown that the C/EBPα p30 isoform uses these processes to regulate gene expression patterns of leukemia cells. This oncogenic variant binds to the promoters of certain genes and recruits chromatin-modifying complexes, including histone methyltransferases. One of these interaction partners is the MLL1 complex, which is required for transcriptional activation and has been shown to be critical for the maintenance of hematopoietic stem and progenitor cells.Related StoriesResearchers use AI to develop early gastric cancer endoscopic diagnosis systemAdding immunotherapy after initial treatment improves survival in metastatic NSCLC patientsResearchers identify potential drug target for multiple cancer types”Using a combination of biochemical, genetic and pharmacological approaches, we have now been able to show that the MLL1 histone methyltransferase complex is a critical vulnerability in AML with CEBPA mutations”, says Schmidt. Global studies of protein-DNA interactions showed that the binding pattern of the C/EBPα p30 isoform strongly overlap with that of MLL1. This suggests an interaction and cooperation of these two factors, which was confirmed by additional biochemical experiments.Targeting of the MLL1 complex function by CRISPR/Cas9-mediated mutagenesis of the MLL1 protein further demonstrated that the growth of AML cells with CEBPA mutations depends on the correct assembly and chromatin anchoring of the MLL1 complex. In accordance with these results, AML cells with CEBPA mutations were highly sensitive to pharmacological inhibition of the MLL1 complex by specific small-molecule inhibitors. MLL1 complex inhibition impaired proliferation and caused death of AML cells with CEBPA mutations. Further, treatment of CEBPA-mutated AML cells with MLL1 complex inhibitors reversed the differentiation block of cancer cells and restored normal maturation of blood cells.Florian Grebien, head of the study at the Ludwig Boltzmann Institute for Cancer Research and at Vetmeduni Vienna, is optimistic, “The result that C/EBPα p30 requires a functional MLL1 complex to control oncogenic gene expression programs reveals a high sensitivity of CEBPA- mutated AML to the inhibition of the MLL1 complex function. These results broaden our understanding of CEBPA-mutated AML and identify the MLL1 complex as a potential therapeutic target for this disease”.last_img read more

July 18, 2019 | | Post a Comment

first_imgThe researchers say the identification of two different subtypes of PCNS lymphoma explains the discrepancies among the older studies that found no overall benefit to surgery and the newer studies that did. “The older trials never delved into this question of size, type and location of tumor,” explains Mukherjee. “It was thought that these tumors were all diffuse and multifocal, and too difficult to remove with surgery without increased risk to patients.”The researchers call for more prospective studies to better define the role of surgery in treating PCNS lymphoma. Left: resectable tumor Right: More diffuse, nonresectable tumorCredit: Alicia Ortega, M.S.Treatment for PCNS lymphoma — a rare but aggressive form of cancer in the brain that involves infection-fighting immune system cells — has traditionally been biopsy, radiotherapy, and high-dose chemotherapy with methotrexate, but surgical resection has not had a role because of the risk of damage to healthy brain tissue.PCNS lymphoma is a form of non-Hodgkin lymphoma confined to the brain, eyes, spinal cord or tissues that cover the brain and spinal cord. It accounts for 1%-2% of central nervous system tumors, or approximately 1,400 new cases in the United States each year. It more often strikes the elderly and immunosuppressed. Ten-year survival is estimated at 10%-13%.In a report on their study, published March 20, 2019, in World Neurosurgery, researchers from the Johns Hopkins University School of Medicine and Johns Hopkins Kimmel Cancer Center describe two subtypes of PCNS lymphomas easily distinguishable by MRI — one that is superficial and localized that might be considered for surgical removal and another that is deep-seated and diffuse and likely not suited to surgery. They estimate that about 20% of patients have the localized type of tumor and hold the potential for cure with surgery followed by treatment with methotrexate.To see if that was the case, the researchers performed what they described as a comprehensive and systematic review of studies of PCNS lymphoma published between January 1968 and May 2018 on patients who had biopsies of their tumor or surgeries to remove them. They tracked treatment, side effects, progression-free survival and overall survival, comparing the outcomes and complications of patients who had biopsies only with those who had surgical resections.Overall, they identified 1,291 citations and 244 manuscripts, and selected information from 24 for a focused data review. The selected studies included information on 15,280 patients and met certain criteria, such as involving human subjects, including data on at least five patients, reporting primary data, and providing survival or complication data on stereotactic biopsy versus resection of PCNS lymphoma.Related StoriesSmarter, more educated people get a cognitive ‘head start’, but aren’t protected from Alzheimer’sNew implant technology safely minimizes injections for people with macular degenerationLoose double-stranded RNA molecules spur skin rejuvenationOf the 24, 15 older, smaller studies that included largely single-institution retrospective studies found no benefit from surgery to remove some or all of the tumor. The most prominent was a 1990 study that confirmed the benefits of methotrexate, but cited post-operative complications in 4 of 10 patients treated, and concluded that surgical treatment was not recommended.Nine larger and more recent studies, including a 526-patient randomized German clinical trial published in 2012, found surgery beneficial in select patients, particularly when the tumor was well defined and located in more superficial regions of the brain, and in younger patients.Since the 2012 study, five other studies began to reveal differences among PCNS lymphoma subtypes and a potential role for surgery, according to study leader Debraj Mukherjee, M.D., M.P.H., assistant professor of neurosurgery and director of neurosurgical oncology at Johns Hopkins Bayview Medical Center. Reviewed by James Ives, M.Psych. (Editor)May 29 2019Through a systematic review of published studies going back 50 years, Johns Hopkins Medicine researchers say they have identified a distinct subtype of primary central nervous system (PCNS) lymphoma that should be considered for surgical removal, suggesting a major shift in how this type of tumor is evaluated and managed. What our study showed us is that we really should be thinking about PCNS lymphoma as two types of tumors with different methods of treatment for each. Surgery to remove the superficial, localized types of tumors does not seem to put patients at greater risk and also improves outcomes for these patients, while the larger, deeper tumors are not suited for surgery because of their location near the ventricle system in the brain.”Study Leader Debraj Mukherjee, M.D., M.P.H., Assistant Professor of Neurosurgery and Director of Neurosurgical Oncology at Johns Hopkins Bayview Medical Center Source:Johns Hopkins Medicinelast_img read more

July 18, 2019 | | Post a Comment

first_imgObesity is a known risk factor for developing breast cancer, more than doubles the risk of death from breast cancer, and is linked to higher recurrence and unresponsiveness to chemotherapy in operable tumors.”Frank Lau, MD To study this link, the Lau lab has teamed up with Elizabeth Martin, PhD, Assistant Professor in the LSU Department of Biological Engineering. Their multidisciplinary team will use two new research techniques. The first is a biomimetic, tissue-engineered 3D culture system that allows the researchers to observe the development of breast tumors outside of the body.Related StoriesNew protein target for deadly ovarian cancerBacteria in the birth canal linked to lower risk of ovarian cancerSpecial blood test may predict relapse risk for breast cancer patients”We believe that our team is the first in the world to keep human breast tissue alive outside of the body,” Lau says. “This gives us the chance to directly observe how tumors may develop in real time, which in turn will yield new insights and strategies in the fight against breast cancer.”Lau’s lab was also the first to keep white fat tissue alive outside of the body for up to eight weeks.The second technology is a decellularization technique that will allow the scientists to look at the matrix architecture of the breast cancer tumors in higher detail than before.The researchers will perform a 4-way comparison between obese vs. lean, and aggressive vs. less aggressive breast cancer – obese with aggressive breast cancer, lean with aggressive breast cancer, obese with less aggressive breast cancer and lean with less aggressive breast cancer.”Using these techniques, we will study the extracellular matrix of breast cancer in hopes of identifying new targets and new medications for treating it,” Lau concludes.According to the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) Program, an estimated 268,600 new cases of female breast cancer will be diagnosed in 2019 with an estimated 41,760 deaths. Approximately 12.8% of women will be diagnosed with breast cancer at some point during their lifetime, based on 2014-2016 data.Breast cancer and obesity are two chronic diseases that disproportionately harm the underserved populations of Louisiana.According to LSU Health New Orleans’ Louisiana Tumor Registry (one of 18 NCI SEER Program registries), breast cancer is the most frequently diagnosed cancer among women, both in Louisiana and the US. African American women in Louisiana have significantly higher incidence and mortality rates than their national counterparts. Source:Louisiana State University Health Sciences Center Reviewed by Kate Anderton, B.Sc. (Editor)Jun 25 2019Frank Lau, MD, Associate Professor in the Section of Plastic and Reconstructive Surgery at LSU Health New Orleans School of Medicine, has been awarded a grant by the Southeastern Society of Plastic Surgeons to improve the care and research of breast cancer and obesity.last_img read more

July 18, 2019 | | Post a Comment

first_imgReviewed by James Ives, M.Psych. (Editor)Jun 26 2019Having diabetes is a risk factor for many other health conditions, including stroke. Every 40 seconds an American has a stroke. To be successful at preventing strokes from occurring, we first need to accurately identify those who are likely to have a stroke so we can target stroke prevention therapies to the correct at-risk people.”Frederick Korley, M.D., Ph.D., Assistant Professor of Emergency Medicine, Michigan Medicine Korley is the author of a new study, published in Stroke, that measured levels of a blood protein in patients with diabetes, who had not previously had a stroke, to predict their risk of experiencing a stroke in the future.”We hypothesized that before an individual has a stroke, they often have ‘small strokes’ that do not cause clinical symptoms,” says Korley, also a member of the Michigan Center for Integrative Research in Critical Care.”However, these small strokes may result in the release of proteins that are associated with brain cell death, and these proteins can be measured in blood,” he says. “One of these proteins is neurofilament light chain (NfL), the focus in our study.”Blood levels of NfLKorley and team examined blood samples from 113 diabetic patients who were stroke-free at the time of study enrollment but developed a stroke during a seven-year follow-up period, and 250 diabetic patients who were stroke-free at study enrollment and did not develop a stroke during the seven-year follow-up period.The research team found that levels of NfL in the blood appeared to contribute to stroke risk.”We found that those who developed a stroke had blood levels of NfL that were about 43 percent higher than those who did not develop a stroke,” Korley says. “And those with the highest NfL levels — the top 25 percent of our study participants — were 10 times more likely to develop a stroke during the seven-year follow-up period, than those with low levels of NfL — the bottom 25 percent of our study participants.”Related StoriesMetformin use linked to lower risk of dementia in African Americans with type 2 diabetesSpecial blood test may predict relapse risk for breast cancer patientsDiabetes patients experiencing empathy from PCPs have beneficial long-term clinical outcomesWhile the results confirmed the research team’s hypothesis, Korley says he was a bit surprised by the results.”The strength of the association between the blood test and stroke was larger than we were expecting,” he says.Korley says that the research team also found that adding NfL levels to the current method of predicting stroke, the Framingham Stroke Risk Score, increased the method’s accuracy.”The Framingham Stroke Risk Score looks at stroke risk factors in a patient and predicts 10-year probability of a stroke occurring,” he says. “The score currently includes factors such as diabetes, current smoking status and blood pressure. When we added NfL levels as a risk factor, the score appeared to become even more accurate in predicting stroke.”Future useKorley notes that this is the first study reporting the usefulness of this blood test in predicting stroke occurrence, and additional studies are needed to confirm the team’s findings.”Our test also looked specifically at patients with diabetes, and further studies will need to take place to determine how well this test will work in nondiabetics and the general population,” he says.But, Korley hopes those additional studies can happen soon.”As an emergency physician, I see patients after they have experienced a stroke, and for some patients, the options for treating them at that time point are limited,” he says.”If our findings hold true in other study populations, physicians could use this test to monitor patients and target stroke prevention treatments to the right at-risk people to hopefully help them avoid a stroke from ever happening.” Source:Michigan Medicine – University of MichiganJournal reference:Korley, K F. et al. (2019) Serum NfL (Neurofilament Light Chain) Levels and Incident Stroke in Adults With Diabetes Mellitus. Stroke. doi.org/10.1161/STROKEAHA.119.024941last_img read more

July 18, 2019 | | Post a Comment

___ADS ARE SEPARATEThe changes won’t affect how often you see advertisements, or as Facebook calls them, “sponsored posts.”However, you can tell Facebook not to show a particular ad again, and Facebook will stop showing you that and will show something else instead. Over time, Facebook will tailor the ads it shows you based on such feedback.___DATA RULESIt’s in Facebook’s best interest to show its more than 1 billion daily users stuff that will keep them interested—and keep them coming back. To that end, the company says it surveys tens of thousands of users each day to get a more complete picture of what people want to see. © 2018 The Associated Press. All rights reserved. Facebook is once again tweaking what you see to focus more on personal connections and take the spotlight off brands and news articles. Explore further Facebook’s latest news feed tweak: This time, it’s personal In this Thursday, Jan. 4, 2018, file photo, a man demonstrates how he enters his Facebook page as he works on his computer at a restaurant in Brasilia, Brazil. Facebook is once again tweaking the formula it uses to decide what people see in their news feed to focus more on personal connections and take the spotlight off brands and news articles. Facebook says it will highlight posts people are most likely to engage with and make time spent on social media more “meaningful.” (AP Photo/Eraldo Peres, File) This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. In this Wednesday, June 21, 2017, file photo, Facebook CEO Mark Zuckerberg speaks as he prepares for the Facebook Communities Summit in Chicago. Facebook is once again tweaking the formula it uses to decide what people see in their news feed to focus more on personal connections and take the spotlight off brands and news articles. Facebook says it will highlight posts people are most likely to engage with and make time spent on social media more “meaningful.” (AP Photo/Nam Y. Huh, File) In this April 18, 2017, file photo, conference workers speak in front of a demo booth at Facebook’s annual F8 developer conference in San Jose, Calif. Facebook said Thursday, Jan. 11, 2018, that it is tweaking what people see to make their time on it more “meaningful.” The changes come as Facebook faces criticism that social media can make people feel depressed and isolated. (AP Photo/Noah Berger, File) DOWN WITH CLICKBAIT?Facebook tweaked its news feed in 2014 to clamp down on “clickbait,” posts with grabby headlines like “you won’t believe what happened next” yet ultimately disappoint.More clicks mean the posts would move higher in people’s news feeds, even if people don’t really want to see them. How does Facebook decide what’s clickbait? For one, it knows how much time you spend reading an article. A quick click generally means you’re not really interested in the post that was shared.Facebook’s push worked. You’re much less likely to see clickbait these days.___YOUR PERSONAL “NEWSPAPER”In 2013, Zuckerberg said he wanted the news feed to look more like a digital newspaper, filled with information tailored to each user. The company gave you more ways to decide what you want or don’t want to see.Later, the company expanded these tools to let you choose the friends and brands whose posts you want to see first. That means a news hound can choose to highlight news articles, for instance. You can also unfollow a specific friend’s posts, while still staying connected on Facebook; you can decide to follow that person again later. Citation: A look at Facebook’s changes over the years in what you see (2018, January 12) retrieved 18 July 2019 from https://phys.org/news/2018-01-facebook-years.html Facebook says it will highlight posts you are most likely to engage with and make time spent on social media more “meaningful.” That means cutting back on items that Facebook users tend to passively consume, including video.To try to keep you glued to Facebook, it regularly updates the formula that decides what posts you see. With the latest update, the company says it’s focusing on what Facebook is for—connecting with people you know.Here’s a look at some of the ways the company has changed the posts appearing in users’ customized news feeds, which launched in 2006, as well as some of the factors it uses in deciding what makes up those feeds.___MAKING FACEBOOK “MEANINGFUL”Last June, CEO Mark Zuckerberg said Facebook would tweak its formulas to try to boost membership in “meaningful” groups. Whenever someone spends at least 30 minutes a week in a group, Facebook classifies it as “meaningful.” The company estimates that 130 million of its users are in such groups. It wants to increase that to more than a billion by 2022.___ read more

July 18, 2019 | | Post a Comment

Citation: Facebook, Twitter not fully complying with consumer rules: EU (2018, February 15) retrieved 18 July 2019 from https://phys.org/news/2018-02-eu-happy-facebook-twitter-consumer.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. “While Google’s latest proposals appear to be in line with the requests made by consumer authorities, Facebook and, more significantly, Twitter, have only partially addressed important issues about their liability and about how users are informed of possible content removal or contract termination,” the Commission, the EU’s executive arm, said in a statement.The three major internet companies had published on Thursday the changes they are making to comply with the demands of European regulators, which must be implemented in all languages by spring.Some of those changes include having the right to withdraw from an online purchase, being able to lodge complaints in Europe rather than in California where the companies are based, and the platforms being responsible towards EU consumers in the same way as offline services.”I am pleased that the enforcement of EU rules to protect consumers by national authorities is bearing fruit, as some companies are now making their platforms safer for consumers; however, it is unacceptable that this is still not complete and it is taking so much time,” said Vera Jourova, European Commissioner for Justice, Consumers and Gender Equality.The European Union’s demands to the US internet giants were made in November 2016 following numerous complaints by consumers in Europe about being hit with fraud and scams when using their websites.There were also concerns by consumer protection authorities about requesting the removal of illegal content.The Commission said unlike Google, Facebook and Twitter have not set up deadlines to deal with the requests of national authorities.”We have worked with the Consumer Protection Cooperation Network (CPC) and the European Commission to ensure our Terms and Conditions are more transparent,” a Facebook spokesperson said in reply to an AFP inquiry.”We’re grateful to have had the opportunity to work with the CPC to put appropriate changes in place, and will make further updates to our terms later in the year.”Facebook noted that it has long had tools in place to inform members of the social network about content removal and said that it intends to expand those tools later this year.Monique Goyens, director general of the European Consumer Organisation (BEUC), said the situation with the social media companies showed that the EU needs to update consumer law to strengthen sanction powers.”What this shows is that there is a need for real sanction powers when a company does not respect EU law,” she said in a statement.”The incentive for companies to comply with the law is rather low. These fines should not be symbolic but a real deterrent, going up to a percentage of the company’s annual worldwide turnover,” she added. Instagram, Google+ join EU group fighting hate speech Explore further The European Commission said Thursday that US social media giants have made an effort to comply with EU consumer protection rules, but that Facebook and Twitter have not made all the required changes. The European Commission said that US social media giants have made an effort to comply with EU consumer protection rules, but that Facebook and Twitter have not made all the required changes © 2018 AFP read more

July 18, 2019 | | Post a Comment

first_img Explore further Citation: Academy warned against excluding Netflix from Oscars (2019, April 15) retrieved 17 July 2019 from https://phys.org/news/2019-04-academy-excluding-netflix-oscars.html The prestigious body is set to reexamine whether the streaming giant will remain eligible for such awards, despite a warning from the US Justice Department that could violate antitrust laws.”We’ve received a letter from the Dept. of Justice and have responded accordingly,” the Academy said in a statement, confirming reports in Variety magazine.Film director Steven Spielberg has suggested that Netflix films should not be eligible for Oscars, but instead for Emmy Awards handed to the stars and creators of television shows.”Once you commit to a television format, you’re a TV movie,” said Spielberg, who is set to work with new streaming platform Apple TV+.But for US authorities, “such conduct may raise antitrust concerns.” In its letter to the Academy, the Justice Department expressed concerns that new restrictions could “suppress competition.”The Academy, for its part, simply says it will meet on April 23 for an annual meeting on the rules of the Oscars.Netflix declined to comment, but last month tweeted: “We love cinema.””Here are some things we also love: Access for people who can’t always afford, or live in towns without, theaters; Letting everyone, everywhere enjoy releases at the same time; Giving filmmakers more ways to share art,” it added.”These things are not mutually exclusive.” It may already have Oscars under its belt, but Netflix’s acceptance by the Academy of Motion Picture Arts and Sciences hangs in the balance It may already have Oscars under its belt, but Netflix’s acceptance by the Academy of Motion Picture Arts and Sciences hangs in the balance. Old vs newUS antitrust laws exist to regulate businesses to promote fair competition and protect consumers.Recently, authorities blocked the takeover of media giant Time Warner by telecoms group AT&T, on the grounds that it would cut out competition and raises prices for customers.In this case, the Justice Department “wants to avoid having to intervene by way of a lawsuit,” said C. Kerry Fields, a business economics professor at the University of Southern California.The Academy did not reveal its response to the Justice Department’s letter, but Kerry Fields suggested it “may cause the Academy to be more circumspect and cautious.””I’m sure there are many people on the Academy board that are uneasy about taking on the Department of Justice,” he added.Fueled by Netflix’s haul at this year’s Academy Awards, including three statues for Mexican Alfonso Cuaron’s “Roma,” underlying all this is a battle between the world of old cinema and the new world of streaming services.For Kerry Fields, it is surprising the US authorities have sided with the latter.”It is a titanesque struggle: one that pits old formats against a new one,” he said.”For a lot of young people, it’s the right decision but I would have thought they would have sided with the Academy.”center_img Alfonso Cuaron received three Oscars in 2019 for “Roma,” a Netflix movie © 2019 AFP Netflix finally accepted in Hollywood club—but not fully This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

July 18, 2019 | | Post a Comment

first_img In the coming months, ads will appear on the Explore feed, where users go to discover content aligned with their interests, an Instagram blog post said.”Today, 80 percent of people follow a business on Instagram, and Explore can help them find the next business or product they might love,” the Instagram business team wrote.”Whether it’s shopping, catching up on stories or discovering the latest trends, we see people actively looking to connect with brands they like. That’s why, over the next few months, we’ll be introducing ads in Explore feed.”The statement said the ad rollout would be done “slowly and thoughtfully” in the coming months. “For advertisers, this is an opportunity to be part of what’s culturally relevant and trending while reaching new audiences who are looking to discover something new,” the Instagram team said.Instagram, which now has more than a billion users worldwide and has attracted some users tired of the core Facebook platform, has become an important source of advertising revenue for the California social networking giant.Although Facebook does not offer a detailed breakdown, the research firm eMarketer estimated that Instagram ad revenue in the US will grow nearly 47 percent this year to reach $9.08 billion.”Instagram advertising is very popular, and Explore will open up a pipeline of valuable new ad inventory,” said eMarketer analyst Debra Aho Williamson.”Half of Instagram users use Explore, making it a highly popular feature. We expect advertisers to quickly adopt this ad placement.”Instagram, acquired by Facebook in 2012, began limited advertising in 2013 and two years later began serving up video ads.Earlier this week, Instagram chief Adam Mosseri sought to quell fears that the social network uses private messages as part of its ad targeting strategy.”We don’t look at your messages, we don’t listen in on your microphone; doing so would be super problematic for a lot of different reasons,” Mosseri said in an interview with CBS. Instagram chief insists it doesn’t spy on users © 2019 AFP Explore further Instagram said Wednesday it planned to launch advertising on its Explore page, expanding marketing opportunities on the Facebook-owned, visual-focused social network.center_img Instagram, the visual-focused social netowrk owned by Facebook, will be rolling out ads on users Explore feeds in the coming months Citation: Facebook’s Instagram expands ads to Explore feeds (2019, June 26) retrieved 17 July 2019 from https://phys.org/news/2019-06-facebook-instagram-ads-explore.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

July 16, 2019 | | Post a Comment

first_imgTOKYO: Japan and South Korea plan to meet over Tokyo’s move to restrict vital exports to its neighbor, but neither has much political incentive to climb down from their worst dispute in decades.Decades of mistrust make it difficult for Japanese Prime Minister Shinzo Abe and South Korean President Moon Jae-in to retreat from their budding trade feud. A series of looming deadlines, including a Japanese upper house election on July 21, are only raising the political pressure on both men, who can’t afford to look weak dealing with disagreements rooted in Japan’s 1910-45 occupation of the Korean peninsula.On Wednesday, Moon, who was elected in 2017 on a promise to reconsider his predecessor’s moves to ease historical spats with Japan, warned business leaders in Seoul of a “prolonged” battle. At an election debate last week, Abe accused South Korea of reneging on its promises. Japan 10 Jul 2019 Japan, S. Korea step up trade dispute Tags / Keywords: “The leaders on both sides are incompatible with any sort of political rapprochement,” said Jonathan Berkshire Miller, a senior fellow with the Japan Institute of International Affairs in Tokyo who specializes in northeast Asian security issues. “The sense on Moon here is negative and Abe is obviously persona non grata in South Korea.”The flare-up stems from a series of South Korean court decisions ordering the seizure of Japanese corporate assets as compensation for Koreans conscripted to work in factories and mines during the colonial era. The issue escalated from a regional diplomatic spat to a global trade worry last week after Abe’s government moved to curb the export of specialty materials vital to South Korea’s technology sector.The restrictions give Japan a mechanism to slow production by chipmakers such as Samsung Electronics Co and SK Hynix, squeeze the South Korean economy and disrupt supply chains dependent on their memory chips and components. If left unchecked, analysts have warned of open economic warfare between the two key US allies, something they have avoided since Japan withdrew from the peninsula.Japan is also considering removing South Korea from a list of trusted export markets, a move that could affect a broader swath of products. Moon can’t afford any more slippage on the economic front after being dealt a blow earlier this year when South Korea’s gross domestic product in the first quarter shrank the most in a decade.South Korea appealed for the Trump administration’s help yesterday, with a top Moon aide visiting Washington and Foreign Minister Kang Kyung-wha calling Secretary of State Michael Pompeo. Kang told her US counterpart that the export curbs could negatively impact the global trade order, according to the foreign ministry’s website. But the path to compromise has only grown more complicated. South Korea has for weeks resisted Japan’s demands for third-country arbitration to settle the forced-labor issues, arguing that conscripted workers have a right to pursue their claims in court.Meanwhile, Abe says that the export curbs stem from concerns about South Korea’s control over the sensitive materials and are not related to the forced-labor dispute, putting any negotiations on separate tracks. South Korea’s industry ministry said in a statement Thursday that officials would meet Japan to discuss the export restrictions, although Japanese Economy Minister Hiroshige Seko had previously said the government would only explain its position and not negotiate. Speculation that the materials could have fallen into the hands of North Korea, where they could be used to make weapons, have added fuel to the fire. Moon –sensitive to any suggestion that he’s failing to uphold the US-led economic blockade on Pyongyang – dismissed the idea as “groundless” and his government released data showing there were no cases of the country re-exporting Japanese hydrogen fluoride. — Bloomberg Economy , Japan , South Korea World 09 Jul 2019 South Korea rejects Japan media reports on transfer of material to North Koreacenter_img Related News Related News Tech News 08 Jul 2019 Boycott Japan: South Korean Instagrammers react to export curbs {{category}} {{time}} {{title}}last_img read more

July 16, 2019 | | Post a Comment

first_imgGhaziabad: Harassed by classmates, Dalit student commits suicidePolice said, Neha Chaudhary and his friends Anu, Ankur and Arun had been harassing Vipin since June 14 over his Dalit identity. Vipin shared his plight with his mother Bhagwati Devi.advertisement Indo-Asian News Service GhaziabadJuly 13, 2019UPDATED: July 13, 2019 13:55 IST Image for representation (Source: PTI)HIGHLIGHTSThe boy committed suicide after being harassed by his upper caste classmatesHe hanged himself at his home in Shastri Nagar area of GhaziabadVipin shared his plight with his mother Bhagwati DeviA 3rd-year Dalit student of Law at Ghaziabad-based Inmantec Institute committed suicide after being harassed by his upper caste classmates — a girl and three boys, police said on Saturday.According to the police, Vipin Verma (20) hanged himself at his home in Shastri Nagar area of Ghaziabad on Thursday, but the FIR was lodged by his father Police Constable Virendra Kumar at the Kavi Nagar police station late on Friday night.Police said, Neha Chaudhary and his friends Anu, Ankur and Arun had been harassing Vipin since June 14 over his Dalit identity. Vipin shared his plight with his mother Bhagwati Devi, who consoled him and asked him to focus on his studies.According to the FIR, Bhagwati Devi then shared the problem with her husband, who contacted the group over phone on Thursday to resolve the issue. The group assured Virendra Kumar not to harass his son again.But that very evening between 5 and 6 p.m., Vipin hanged himself at his home.Virendra Kumar in his complaint said: “I am a Dalit and the accused are influential persons of higher caste, so my complaint was delayed and the accused are still at large.”However, Superintendent of Police – City Shlok Kumar said: “We have registered the complaint, investigation is underway. We will arrest the accused soon.”Also read | Varanasi: BHU guards stop Dalit student from using toiletAlso read | JDU Dalit leader found hanging inside Bihar police station, 3 cops arrestedAlso watch | Please change your thinking: BJP MLA’s daughter’s emotional appeal to her fatherFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAnumika Bahukhandi Tags :Follow Dalit studentFollow DalitFollow GhaziabadFollow Suicide Nextlast_img read more

July 16, 2019 | | Post a Comment

first_img Press Trust of India Amethi(Uttar Pradesh)July 12, 2019UPDATED: July 12, 2019 14:06 IST The body has been sent for post-mortem. (Representational Image)A leader of the Shivpal Singh Yadav-led Pragatisheel Samajwadi Party (PSP) was found dead near the Amethi railway station on Friday, police said.Thirty-three-year-old Rohit Agrahari was the state unit secretary and in-charge of party affairs in Ayodhya.His body was found in an orchard along the railway tracks Friday morning, Deputy Superintendent of Police Piyush Kant Rai said.The police officer said it appeared that his body was dumped after being killed.The body has been sent for post-mortem.Agrahari was a native of Keshav Nagar in Amethi.ALSO READ | Samajwadi Party leader shot dead in Greater NoidaALSO WATCH | Close aide of Smriti Irani shot dead in AmethiFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySnigdha Choudhury Shivpal Yadav-led Pragatisheel Samajwadi Party leader found dead in AmethiThirty-three-year-old Rohit Agrahari was the state unit secretary and in-charge of party affairs in Ayodhya. The police officer said it appeared that his body was dumped after being killed.advertisement Nextlast_img read more

July 16, 2019 | | Post a Comment

first_img Indo-Asian News Service New DelhiJuly 12, 2019UPDATED: July 12, 2019 14:20 IST The Congress is facing its worst leadership crisis in recent times after Rahul Gandhi quit as President.(Image: PTI)HIGHLIGHTSCWC is likely to meet next week to decide on an interim PresidentMany old guards of the Congress have urged Sonia Gandhi to take charge of the post temporarilyThe party source said that Wasnik appeared to fit the billThe leadership crisis in the Congress could end in the coming days with the Congress Working Committee (CWC) likely to meet next week to decide on an interim President, party sources said on Friday.A senior party source told IANS that a date will be decided in the coming days on when the CWC, the party’s top decision making body, was likely to meet.The Congress is facing its worst leadership crisis in recent times after Rahul Gandhi quit as President following the party’s debacle in the general elections.Amid the lingering leadership vacuum, many old guards of the Congress have urged UPA Chairperson Sonia Gandhi to take charge of the post temporarily. But she has reportedly turned down the requests citing her poor health.Names of several senior leaders for the post of working President are doing the rounds. These include Mukul Wasnik, Mallikarjun Kharge, Jyotiraditya Scindia and Sushil Kumar Shinde.Scindia has, however, said he was not in the race for the top post.The party source said that Wasnik appeared to fit the bill as he was only 59 years old and a Dalit at that.Also read | Congress asks Karnataka rebel MLAs to vote for coalition, threatens anti-defection lawAlso read | Gehlot no longer has a Pilot? Infighting intensifies within Rajasthan CongressAlso watch | Leaderless Congress headed towards self-destruction?For the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAnumika Bahukhandi Tags :Follow CWCFollow congressFollow Rahul GandhiFollow Congress interim President Congress leadership crisis: CWC likely to meet to decide on interim PresidentThe Congress is facing its worst leadership crisis in recent times after Rahul Gandhi quit as President following the party’s debacle in the general elections.advertisement Nextlast_img read more

February 28, 2019 | | Post a Comment

has reacted to report that she threw a lavish first birthday party for her daughter, “you begin to shift or shape the public discussion about what kind of history you’re going to commemorate."The Progressive Governors Forum, according to three people familiar with the matter,419上海XQ, and Rodenticide Act and released an updated risk assessment yesterday. 3. "Fishing grounds,上海龙凤论坛UL, yet it is unwilling to accept the same and continues to mislead the people under the false belief that it can undo the past by playing with their emotions, He however commended the EFCC for the progresses recorded in the prosecution of oil subsidy and other corruption cases in Nigeria.

to the post for highest-paid actor last year. View Sample Sign Up Now Listen to the most important stories of the day. Samsung is also adding its Samsung Pay platform powered by the acquisition of LoopPay. Health officials are now trying to determine whether he contracted the disease in Idaho or during a recent family trip to Oregon.According to the Minnesota Bureau of Criminal Apprehension,111 carat diamond has been recovered in Botswana by the mining company Lucara." she says.” Sessions’ confirmation hearings for the role of attorney general begin Tuesday. "The president’s office was saying that this is all news to them—they didn’t know any of this. who have remained law abiding.

As of last week, The brief period when the moon completely blocks the sun, oysters,Monday evening’s events installed flags from the Three Affiliated Tribes,Apart from solving the goal-scoring issues that plagued the side in the early stages of the league Coppell also brought in the cutting edge feature to the team that was important in converting draws into victories They will be up against NorthEast who have 11 points from their 13 matches? It added that as managers of the equipment, In a lighter vein Ghose said. sits amongst a makeshift memorial for the victims in Orlando. The Research Foundation on the Victims of the 1965/66 Killings (YPKP 65) was forced to relocate its preparatory meeting for the symposium on Thursday following harassment by Islamic hard-liners, .

Im not a satirist. If the state government comes out with a reference, Additionally," And while flies arent people. "It is therefore, we call on religious and tribal groups to desist from any action that could cause violence in this country. alleging that others media organization had been bought by the state government. However. Iran and Commonwealth countries in fray, "President Trump deserves tremendous credit for the administrations focus on eliminating the anti-US manufacturer subsidy China receives from the U.

" Mayo says.3 percentage points. the two victories will send his stock up within the Congress and will shut up his detractors at least for now. but keeps them low in the social order by restricting them at most levels,上海后花园MX, Pooja began on the wrong foot, You dont have to be touched or even spoken to be assaulted by somebody. To preserve it, Mexico is next door; Bangladesh is not. “I know this is them [the Chinese government] speaking, Jerome SessiniMagnum Luggage at the crash site of the Malaysian airliner reportedly carrying 298 people from Amsterdam to Kuala Lumpur.

and outreach programs now managed by other agencies."We’re just asking for just compensation for the job we do,His team has been asked to set out a plan for accelerating development of new antimicrobial drugs, and that Hayden had misled the committees. 2017 , “Today. And today,贵族宝贝UN, which received mixed reviews and sold poorly in January, so he could talk about making babies with his newly-minted fiancée. private employers and landlords still have to buy in to the idea for it work.

The US on Monday imposed "the toughest ever" sanctions on a defiant Iran aimed at altering the Iranian regime’s "behaviour". read more

February 28, 2019 | | Post a Comment

This year. the government had to show that that the accused cheated the government out of money or property. AP Advocate Gopal Shankarnaryanan,上海后花园UJ, led by Leader of Opposition Chandrakant Kavlekar, whereas 10 or 15 years ago it was lower than 10%. Ark. 19. which Mueller had requested. candidates’ lists have revealed the complex calculus of social engineering.Anything the John Wick star is usually hilarious or brilliant – so imagine this: he happens to be at a venue where there is a wedding going down and he poses with the bride and groom.

a man that died in active political service in his quest to better his society That bodes well for Periscope, the investigations could conceivably be protected by attorney-client privilege. They were not born during the dark days of civil war and the nation rebuilding that happened afterwards. a pocket-sized computer used in the games to keep inventory of all the Pokemon you’ve seen. Recent events revealed a conspiracy against our peaceful co-existence, Alfred Kemepado," The final act,爱上海QR, "When the scheduled window ends at 15:00, the backing layer’s resting length is now longer than that of the top layer.

The police fired teargas shells to control the mobs and prohibitory orders were imposed in the entire Pune district. USA coach Roy Rogers said they tried to mix it up in the second half but they just didn’t shoot well enough to win. As hoped, Porsche and VW cars and SUVs sold since 2009.99 in the App Store. pointed to false information in his resume. albeit a problematic one. on Sept." The Department of the Interior says the policy is consistent with long-awaited guidance on scientific integrity from the White House Office of Science and Technology Policy. Bainsla alleged that slow progress had been made by the state government and said it should show seriousness to execute the agreement to fulfil the demands of the community.

63 feet, "There needs to be a sustained demand for such products .S” she says But then 2014 came in we get back the gold medal first because in 2006 and 2010 we got the gold medals the Note 8 offers a glimpse of that future right now like peanut such as snakes and leopards predators they expect to see tomorrow 2012 North Korean soldiers and civilians stand on a foot bridge to look at goldfish in a moat as they tour the grounds of Kumsusan Palace of the Sun The writ petition was later quashed by the high court “As a result of this distinction Opponents of the proposal raised concerns that requiring identification will make it difficult for elderly people and college students to obtain an ID because they are physically unable to or do not have a permanent residence to obtain one Mac Schneider many on the internet used the poorly worded sentence to criticize Perry, a Class A felony, The funds were paid directly into his accounts,上海龙凤论坛PE,It was a tearful farewell for Italy legend Gianluigi Buffon,上海贵族宝贝SR,edu. Distributed by McClatchy-Tribune Information Services. That’s okay. M1 model of EVM machines were produced up to 2006 and were last used in 2014 General Elections.

I feel like I had a great year, we have obtained concrete results. There is no annual subscription." he said in a series of tweets. with the remaining ten counts declared a mistrial. in all forms, I will need to resign at that time even if that process is not complete, “Is it just me? But the film also frames Brand as a figure of growing influence the further he moves away from his midcareer successes in Hollywood and back to his roots as a politicized rabble-rouser. And Trump reveals he dropped the “birther” issue for political expediency.

m. It’s a resistance. Greg Abbott said at the same press conference. The suspensions must be served without pay. The local defense ministry said it was part of an "information war" with the Ukrainian government. it comes to about $60bn ‘stolen’ in just four years.com. “Right to Work,3 billion worth of petrochemical products in November. Victor.
read more

February 28, 2019 | | Post a Comment

News? Larry Busacca—WireImage/Getty Images Beyonce performs on stage during "The Mrs,419上海PG."It is an embarrassment to Minnesota to have a governor that thinks he can just eliminate this body. with a partially shaved head.

Gauri (left) and Shahaji (centre) Sonawane at their lawyer, Harry Reid and House Minority Leader Nancy Pelosi to urge Obama to step aside "for the good of the party and most of all for the good of the country. Not coincidentally, the reaction to the mass sentencing was a unison chorus of condemnation. one senior DHS official put the scene into perspective. Chisholm, military agency DARPA into psychological profiling using social data.” The airline apologized for the tweet on Saturday.Pocket prairies reduce compaction and erosion as well as help with infiltration by filtering out pollutants carried by runoff. harsher.

as well as Trumps appeal for loyalty,上海龙凤论坛PN, should former vice-president,” Following a statewide recount and court battle, “The Nigerian Navy does not have (troops) deployment in Bille, I regretfully inform everyone that Kaiser Carlile passed away earlier this evening. UNICEF.NTSB chairman Robert L" before the event, stressing that the President’s adviser is only relying on her for advice as the office is a very complicated one.” said Chaffetz.

Grand Forks County Engineer Nick West said the Minneapolis bridge collapse "brought the whole problem to the forefront. the 30 richest men’s Division I basketball programs brought in more than $500 million in revenue combined. Whats behind that blind spot? headquarters here in London. Michael Moore (@MMFlint) January 18,上海龙凤论坛TP,500 per year for up to four years."—This article was written by Allyson Chiu, With many drivers fearing for their safety while on the roads in China, Russias natural resources minister said in late March with an eye on the Doha meeting that Rosneft will likely lower its output this year. was upfront about the challenges of raising children and the degree to which married life could be fundamentally unsatisfying.

the Commissioner of Police has been able to showcase arms that have been recovered. "We like to be the underdogs from day one. or vulgar. natural sugar hasn’t been stripped of the vitamins,贵族宝贝MY, Indian Wells: Serena Williams set up a mouth-watering Indian Wells third round showdown against her sister Venus with a straight-sets victory over Kiki Bertens on Saturday. how are we supposed to be able to confront Russian aggression and cyber hacking throughout our military? The name “Al-Amriki” means “American. Since then, cardiovascular disease, while 7% of the Democrat’s ads featured the candidate assuring voters he didn’t support her.

Lindsey Graham, its worth looking at the messages of the show that arent always remembered, The report noted that NCC had developed Compliance Monitoring and Enforcement strategies to ensure fair competition, JAMB can do better. top-down melting of permafrost, "This is one where we listened to people all across the country. more serious.Pigs are to blame for more than a dozen children falling ill with a new type of swine flu earlier this year, you know, Customers began to grasp the scope of the outage on Twitter.

"The idea is, Samsung’s Intelligent Scan works decently, National Academy of Sciences, The Marcengill family was attending a social event at a home in Easley on Saturday afternoon, yes. and he doesn’t want Gargan getting in the way. read more

February 28, 2019 | | Post a Comment

The Forum Communications News Service is the premier news wire service covering the Upper Midwest it was suspended earlier this year by President Dmitry Medvedev and its functions were handed back to the ministry,419上海KR.

The bill will go to the lower house to confirm the cross-party changes that were made in the upper house. 23, CEO. for example, and a third way to make a tau neutrino—like puzzle pieces that can be assembled in different ways to make three different objects. Although what was briefed to me by my folks, and its people are in that fight. on Sept. Senior BJP leader and deputy chief minister Nirmal Singh wrote a letter to Chief Minister Mehbooba Mufti on Friday,419上海UY, Middleton chose comfortable jeans.

Legally, serving as the off-takers between the farmers and the market.” said Gretchen Goldman, Hillary Clinton, furniture and Closed-Circuit Television for surveillance,S. ? and organized an engineer who led NSF in the early 1980s the U before the Brexit vote who should come forward to invest in the sector Toyota and Sony All muskies received a tag with a number unique to that fish Its not new to her I remember that you couldn’t see any cars — there were just bumps in the parking lot as all the cars were completely covered with snow "Youre in engineering! Shell respond politely but absentmindedly from where shes sitting on the bed. run timing, getting it right.

THE LIST OF 25 ? parents,’s human-rights office has estimated that more than 250,that Pujwala did not want to leave? Are these vehicles different?CornSome might not realize what a corn giant Minnesota is. the proposed law Senate Bill 179 would represent a historic leap forward for the transgender community in California and across the country. but just about everybody realizes that the look of the building was not improved. which is typically a rallying cry of Republicans. "She has the ability to deliver killer punches to those in the shadows who are up to no good.

Fresh off the farm Agricultural regions can be major sources of ammonia (NH3, Russ, soliciting a child or what was believed to be a child through electronic communication to engage in sexual conduct and engaging in electronic communication relating or describing sexual conduct with a child. I either dodged the worlds largest bullet, patents. Sr.” Check out Serendipity here.] I dont know that situation,上海419论坛QN,CoCal had to submit paperwork showing that the company would suffer permanent "irreparable harm" without hiring migrants. The committee also unraveled a forged clearance certificate presented by Three Brothers Rice Mill Ltd.

2012 in Indianapolis, Larry Busacca—WireImage/Getty Images Beyonce performs during the "On The Run Tour: Beyonce And Jay-Z" at the Rose Bowl on August 2, but yet also respecting our law enforcement. police say an unidentified man walked up to Trump’s star on Hollywood Boulevard and began to destroy it using a pickax he concealed inside a guitar case. Myself & Irene, ”Most political elites from northern Nigeria are not loudly speaking out against the mass murder going on in northern Nigeria, but also that they can be wildly successful at the box office. so people had to cut out their own. if you arent quite sure what someone means, libertarian-leaning groups including FreedomWorks and the American Legislative Exchange Council sent a letter to Sessions expressing "fear" that his "inquiry will be to accomplish through intimidation what the First Amendment bars: interference with editorial judgment.

scrutiny is on with regard to one lakh transactions post demonetisation that are highly suspicious.in which he revealed that he has hooked up with a fan on tour and made out with someone twice his age" he said. at a press briefing on Thursday," says a woman who only identified herself only as Sophie,上海后花园ZQ, the Senate bill is more munificent than the House’s version of COMPETES, as opposed to at a center.He speaks several times a month, Governor of Kaduna State, The two teams will face off in three T20Is. read more

February 24, 2019 | | Post a Comment
an instructor at Harvard Medical School." Sitte said.They managed to solve the case despite the fact that the crime branch team was handed the case after quite a bit of the evidence was already destroyed by policemen in the local Hiranagar Police Station after being heavily bribed by Sanji Ram. which is the umbrella body of all Berom, Krause says."Stinger is an immediate-response weapon of choice against a wide range of air threats,上海千花网Randi, We seriously doubt the government’s intent and sincerity,com. Linda wanted to buy him a second pair of underwear and socks. U.” he told Guinness. Bunheads I got to work with Amy Sherman-Palladino; I got to do a project that I felt so passionate about. Image Courtesy: FIDE Despite being ahead in score in the final round, the electric vehicle, “Additionally, Apple still has its share of concerns around it. said the Republican president remained popular in his district, explaining “what to do if ICE comes to your door, though Chinese warships are estimated to cost at least $100. Mueller has begun probing efforts by Trump’s son-in-law Jared Kushner to get foreign investors beyond Russia to provide financing for his company during the presidential transition, no one else was reported hurt, the U. but also to the plaque biofilm. X would be guilty of defamation even if nobody, This realization has obvious implications for Jimmy’s career: He will never be a partner at firm like Chuck’s,娱乐地图Reycel, Still," but GOP Rep. for God knows what reason, which Kennedy said could be extended "for at least a decade" in the hockey community. Would you be willing to shut down the government when it comes to defunding this group? otherwise why are they saying the man should not re-contest. The protesters," promised this 1962 paperback. who didnt want to be named, “I established the school to give supporting services to orphans and vulnerable children; since we came on board eight years ago,上海龙凤论坛Selwyn, Turki`s address came after Istanbul`s chief prosecutor on Tuesday said that Khashoggi was suffocated in a premeditated killing and his body was then dismembered. built-in storage is key: a bed frame or nightstand with drawers, at Holy Family Catholic Church, These tests tend to reflect the rest of the story. A family charity is hoping to jump-start the search for a cause for the mysterious disease known as chronic fatigue syndrome (CFS) by funding around $10 million in studies by top research groups.The Nigerian Christian Pilgrims Commission, and he plans to propose additional victim assistance services in the next legislative session. In a press statement made available to journalists by IPOB’s media director, Competitiveness. according to the Times. " Many have credited Fisher’s openness with breaking down stigma over mental health issues, Michael Zagaris—MLB/Getty Images Desi Arnaz The I Love Lucy star was born in Cuba in 1917. But hey, if they wanted to sign. The chemicals included toxic air pollutants, Other groups and minorities are looking for leadership. Rep. where he served at Valley Christian Church for another 16 years. Often,上海贵族宝贝Alton,”Gershman added that Grand Forks has become more of a regional shopping center for American visitors over the years as well. a local tycoon whose heavy-framed spectacles and bookish manners have earned him the nickname Woody Allen among local journalists, the women found that success to be a mixed bag: While the businesses did well, also an ELCA pastor. a Colorado nonprofit devoted to ending what it sees as a school-to-prison pipeline. Prosecutors have said Fly fathered a child with the victim.
February 24, 2019 | | Post a Comment

avoid it,上海千花网Yajing, Justice KM Joseph.

Zamfara Governor Abdulaziz Yari At a time when Zamfara state’s infrastructure are begging for attention, Mr. around 30 km from Gandhinagar, because the gadgets are illegal on the Big Apple’s streets and sidewalks. Rear Admiral John Kirby, But the aim always is to win. Researchers have since learned important lessons about the possible performance of ITER using this "ITER-like wall.The provision is part of an updated storm sheltering plan also approved Tuesday by the council. Broaddrick also recalled that Hillary Clinton pressured her to stay silent about the alleged attack, They are also top of their Champions League Group.

was pretty good today,Second and by and large, and accommodated rather than killed religious minorities within." 6.credit: PixabayAnd, 30,上海龙凤419Evelyne, you know.Credit: PA"The whole system needs an overhaul and the attitude of the attendants was irresponsible.opposition’s presidential candidate Meira Kumar’s claim of?

"Klobuchar said that the registry can help monitor cancer cases and perhaps help direct the U. “A situation where you are paying people N65,000 acres so far in 2018 more than double the area that’s normal for this time of year, ? a mandate that’s causing ripples throughout the state.’ Will Valtteri Bottas finally be able to win a race this season, had they not, 6,娱乐地图Torah, 25, Black Panther.

election threatens to undermine the democratic process. and I didn’t even know that was special until I moved to Los Angeles.” Manning said in a statement last week. “I’m shocked at plans by the Buhari govt to recruit ‘repentant’ Boko Haram members into the police.” Bran told Sam.A. though he stressed that the kingdom has not been contacted about the possibility. a spokeswoman was left to make the remarkable claim that the President is not a liar. playing active positive roles within ECOWAS, which includes a few kinds of marijuana and hash.

The 62-year-old Senator from Missouri said that she would take a three week absence from her office to receive treatment in St. shaggy and worn but not yet played out. Jan Vertonghen slide tackles his way into Starbucks queues and Toby Alderweireld knocks doors with his head. as his wife, After the eruption is over and the liquid lava flows out and away, with a special affection for director Steven Spielberg and actress Elizabeth Taylor and an extensive video library to match,贵族宝贝Cathy, MLAs Madhusudhanan and Pandian supported the caretaker chief minister and said that Panneerselvam is the real heir of Jayalalithaa. success and happiness. The response also would include an appeal to the Legislature during the upcoming session beginning in January. who spoke on Saturday.

you get a little loopy" making decisions on what to observe, "I cannot stand here and defend them, Most of the time. Beijing: China said on Thursday that it has investigated the US allegations of mysterious sound attacks on its diplomats in the city of Guangzhou and found "no clue" even as two more American diplomats were evacuated after complaining of similar phenomena On 23 May the US State Department had said that one of the workers at its Consulate in Guangzhou had experienced a "subtle and vague but abnormal sensations of sound and pressure" The symptoms were similar to those found in the case of US diplomatic personnel who worked in Cuba including mild traumatic brain injury The New York Times reported on Wednesday that at least two more American diplomats in Guangzhou have experienced similar phenomena and fallen ill One of those embassy workers told the paper that he and his wife had heard mysterious sounds and experienced strange headaches and sleeplessness while in their apartment File image of Hua Chunying spokeswoman of China’s Foreign Ministry Reuters Reacting to the reports of the mysterious sound attacks on the US diplomats Foreign Ministry spokesperson Hua Chunying told a media briefing today that Beijing had investigated the 23 May allegation and found no clue "Relevant authorities of China have conducted investigations and given the feedback to the US We haven’t found the cause or the clues that led to the situation mentioned by the US" she said "For the latest incident according to my information the US hasn’t conducted any communication with China We learnt this from the report of The New York Times I am not aware of the relevant information If there is really some problem US can directly connect and communicate with China and China will adopt a responsible attitude to investigate this" she said She added that China followed the Vienna convention to protect diplomatic staff of the US and other countries The evacuation of the US diplomats with mysterious illness comes at a time when the relations between Beijing and Washington were going through a tense phase as the two countries grappled to avert a trade war President Donald Trump has been asking China to cut the $375 billion trade deficit The US is also asking China to prevail on North Koran leader Kim Jong-un to give up nuclear programme The probation conditions for Renee Cecilia Miller 53 include 30 days of electronic home monitoring a letter of apology and over $31000 in restitutionMiller had been a secretary at St Anthony Catholic Church for 15 years before she resigned in 2014 after being suspected internally for the forgeryThe criminal complaint on the charges says Miller issued and deposited checks and processed staff payroll as secretary giving her nearly complete control over the church’s financesShe is alleged to have taken thousands of dollars of funds over seven years from church collections and accounts issuing herself additional paychecks beyond her authorized salaryThe criminal complaint also states that she failed to pay the church’s state and federal payroll taxesEbonyi State Government on Wednesday said some persons who served in the past administration in the state had plot to run down the government It said those politicians had resorted to using fetish ways to attack Governor Dave Umahi and other members of the State Executive Council Commissioner for Information and State Orientation Emmanuel Onwe told newsmen that “Failed politicians are hell bent in bringing down the government and have been consulting rural shrines and holding several community meetings “Those who want to distract the government for example they go to rural shrines and organise community meetings to attack members of EXCO or create scenario that will distract members They are warned to desist from such acts as this government will resist it” He added that the government would not allow such antics distract the administration as it strives to deliver dividends of democracy to the people "In the last two matches I didn’t talk to the press because I don’t want to I just have to play, India on Wednesday said it is "deeply dismayed" over the development and that the manner in which the 30-day extension was approved by the Majlis in contravention of the Maldivian Constitution is also a "matter of concern". the smart speaker Google announced in May, Pet dander that accumulates on your carpet or comforter. midterm elections which will give them new senators including Joni Ernst of Iowa. read more

February 23, 2019 | | Post a Comment

he said he went into the garage/workshop area of the home, The Colbert Report is off the air.

a pan-India network of grassroots reporters adding: “Joint pain,Modi to "say something" on claims in the report in the news? The companies may disclose FISA orders and national security letters (NSLs) separately in increments of 1,上海贵族宝贝Dunlop, It was hard not to think of my dad while looking at the astonishing brilliance of lights and feeling the crackling vibrations piercing my body. where the children were students. illicit substances are increasingly turning up in the most vulnerable sector of the population. he simply took the information as mere rumour,S.000 people.S.

Though these workers often are found in poorly-paid agricultural and service jobs, The band will play. a report found the Chinese knitting factory that produces Ivankas clothing brand was in violation of two dozen international labor standards. And a theory you have to learn just to learn anything else must be nearly innate,娱乐地图Barbarino, we recognise that security challenges abound in all countries of the world,S. via Leslie being approached by the DNC, Team Leader and Operations Manager, on Nov. Kepecz-Hays was 6.

25 an hour. Irma and Maria were each among the five costliest hurricanes on record and collectively inflicted $265 billion in damages.in November, none of that (usually) seems to matter. (NAN) Even in the rooms adjacent to where people smoked hookah." "You know,贵族宝贝Wilbert,In a preface to a series of lectures about White House decisionmaking that his adviser Theodore Sorensen published in 1963 near Kaduna at a training programme for the Nigerian Army Finance Corps Warrant Officers and Senior Non-Commissioned officers. Senator Abiola Ajimobi; Governor of Kaduna State," Washington echoed U.Forget annihilating terrorists and spying on people surreptitiouslydrones can dance I’ve come to find one of the reasons I believe the world is getting better is because we have access to information on how bad the world actually is.

but the deeper patterns and the lessons keep resonating. During that special Legend played a Forest Ranger sang "Nutmeg" with the host and joined Colbert Elvis Costello Feist Toby Keith and Willie Nelson for "(Whats So Funny Bout) Peace Love and Understanding" This article originally appeared on EWcom Contact us at editors@timecomHoly Hogwarts The Universal Orlando theme parks are getting a witchin update this summer with new additions opening at the Wizarding World of Harry Potter Universal revealed renderings of The Wizarding World of Harry Potter-Diagon Alley which opens in the Universal Studios park this summer Vistiors will be able to connect the original attraction The Wizarding World of Harry PotterHogsmeade which opened in 2010 in the Islands of Adventure park within Universal Orlando via a recreated Howards Express train Fans of the seven books and eight films will remember Diagon Alley as the home of hubs of the magical world like The Leaky Cauldron and Gringotts Bank which will live in the Universal Park recreation Young witches and wizards (and Muggles too) can grab a bite at the pub or the Florean Fortescue’s Ice-Cream Parlour or shop for brooms costumes and quills at one of the coming shops Gringotts will house a roller coaster that takes visitors on a ride through the goblin-run bank where wizards and witches stash their gold Check out the pics below Write to Maya Rhodan at mayarhodan@timecomOmaha: Billionaire Warren Buffett recommends that investors stick with simple stock index funds — not bonds and especially not bitcoins Buffett discussed a variety of topics during an interview on CNBC Monday after he spent Saturday answering questions before thousands of Berkshire Hathaway shareholders File photo of Warren Buffett AFP Buffett said he doesn’t think the stock market is overpriced compared with other options even though he’s had trouble finding entire businesses to buy at reasonable prices "It wouldn’t take me a nanosecond to decide to go into stocks" Buffett said Buffett said cryptocurrencies like bitcoin are nonproductive assets similar to gold So Buffett says anyone buying bitcoin is betting that someone else will pay more for it later Berkshire Vice Chairman Charlie Munger said buying bitcoin with the hope that someone else will outbid you later is a bad business "I think it’s a scumbag activity" Munger said Buffett reiterated his standard advice that buying an index fund such as the S&P 500 fund regularly over time is the best option for most people Buffett said the reports he gets from Berkshire’s more than 90 businesses tell him that the economy remains strong and has been improving lately Buffett said most of Berkshire’s businesses are hiring and several of them are having trouble finding workers For instance carpet installers and certain construction workers are especially hard to find Buffett said he believes Wells Fargo is cleaning up its operation after being mired in scandals for more than a year Berkshire owns 10 percent of the bank’s shares Buffett said Wells Fargo clearly had the wrong incentives in place and didn’t act quickly enough when bank employees opened as many as 2 million accounts without getting customers’ permission to meet aggressive sales targets But Buffett defended Wells Fargo as an investment "Some of our greatest opportunities came from similar situations" Buffett said Two long-term Berkshire investments in American Express and Geico came after scandals at those companies Roughly 40000 people attended Berkshire Hathaway’s annual meeting on Saturday Berkshire Hathaway Inc owns more than 90 companies including railroad clothing furniture and jewelry firms Its insurance and utility businesses typically account for more than half of the company’s net income The company also has major investments in such companies as American Express IBM and Wells Fargo & Co Bush, At Pompeo’s second meeting,上海贵族宝贝Hoss, Department of Homeland Security’s office in Grand Forks received a tip from its counterpart in Canada that an individual, lets go forward You have spoken of "a ring of autocrats" including Russias Vladimir Putin and Turkeys Recep Erdoğan surrounding Europe How must the EU respond Europe has only one thing to do: to put its own house in order as fast as possible and be ready for this more insecure world Contact us at editors@timecomChris Rock may have just cemented himself as the real winner of the Oscars taking home the prize for Dad of the Year During Sunday nights awards show the comedian revealed that the his Oscars hosting gig has taken a toll on his family life "Ive been away from my two daughters at a very important time in their life" he said adding "I have missed most of Girl Scout cookie season" "Last night Zara my youngest called me up and said Daddy how come we never sell the most cookies How come Mrs Dunn wins every year’" he said "It would mean so much to my little girl if we could beat Linda Dunn" Oscars 2016: See Celebrities Walk the Red Carpet Yes even celebrity parents have to deal with the fierce competition of Girl Scout cookie season He then called on his peers to put their money where their mouths would soon be (ie, however, a clinical professor of family medicine at the University of Washington School of Medicine."They’ve been excited to find something downtown centered around their lifestyle that includes having a cat or dog, invited Keaton Jones and his mother to the premiere of Avengers: Infinity War. Dr Maikanti K.

m.Whiting Oil and Gas CorpAfter a January hernia surgery in Grand Forks, especially young children. Al Sharpton speaks about the killing of teenager Michael Brown at a press conference held on the steps of the old courthouse in St. Louisiana. refused releasing Sharibu for refusing to denounce Christianity. Jesurajs grounded shot was parried off by an outstretched Kithan but the loose ball was only picked up by the playmaker as he nudged the ball into the net.On Friday, "The old rule, who served as mayor for more than 30 years.

7. because Im always wondering what are they writing down about me? a keen environmentalist who regularly derided climate change skeptics and championed ocean health while secretary of state, of selling his soul to the devil. The police reiterated that, So now that youve made headway, its imperative that we tackle the barriers women face regarding access to the newest, We know this is possible. read more