Category: kcmgstve

March 2, 2021 | |Post a Comment

first_imgToday, Grateful Dead guitarist Jerry Garcia would have turned 76 years old. A hero and icon in the San Francisco psychedelic-rock scene and beyond, he sadly did not get to experience much of his 54th circle around the sun. Jerry passed away eight days after his 53rd birthday, on August, 9th, 1995.To celebrate Captain Trips birthday this year, his daughter, Trixie Garcia, has shared a short message and big surprise for fans. Read Trixie Garcia’s statement below:Dear Fans and Friends!It’s that time of year again when we celebrate the legacy of our dad, Jerry Garcia! To honor Jerry’s birthday this year we are giving away 90-day Nugs.net memberships so that you can listen to Jerry’s catalogue and explore all the other great artists that our friends at Nugs.net stream! To unlock your membership, join the email list at Jerrygarcia.com and you’ll receive a unique code via email within 24 hours of signing up. Let’s remember the good times and keep the love alive!Peace and Love,Trixie GarciaThat’s right! Free 90-day Nugs.net memberships for all! Just join the email list on Jerry’s website and you will receive a unique membership code within 24 hours of signing up! Happy birthday, Jerry! You know our love will not fade away…last_img read more

March 1, 2021 | |Post a Comment

first_img Related Harvard-trained doctor David Sachar and Brigham and Women Hospital’s pathologist and senior lecturer Noel Rose have been recognized for their contributions to medicine with this year’s Golden Goose Award.Sachar was recognized for experiments with frog skin that led to the development of oral rehydration therapy, while Rose was honored for using a rabbit to prove that an autoimmune response can cause a human disease.The award is given each year to scientists selected by a bipartisan committee of congressional supporters and several science societies and organizations. The Golden Goose Award got its name from vocal critics of curiosity-led science, which can lead to transformative benefits to society. In response to claims that federal investments in such research was wasteful, a coalition of business, university, and scientific organizations came together with the American Association for the Advancement of Science (AAAS) in 2012 to recognize the importance of “blue-skies research.” Rep. Jim Cooper (D-Tenn.) championed the idea of the Golden Goose as a fitting analogy, and it stuck.Though most scientific research is carried out in universities and institutes with their own infrastructure, national funding stimulates exploration and keeps the enterprise competitive. It also saves governments from the financial, political, and social costs of sustaining vast research operations within their own brick-and-mortar facilities.“Government-funded research is vital for America’s future and the future of the world,” Cooper said in a statement from AAAS. “Taxpayers have received untold benefits from breakthroughs that have lengthened and enriched our lives. Let’s keep progress on track by boosting funding for research!”A simple solutionWhen Sachar graduated from Harvard Medical School in 1963, he was so inspired by his class speaker, Nobel laureate Thomas H. Weller, M.D. ’40, that he decided to dedicate his two years of government service to making a difference in the developing world.“Weller said that if we worked very hard we could advance the average life expectancy of someone in the United States a few years at best,” he recalled. “Then he said that if we spent just one-tenth of those efforts in the developing world, we could advance life expectancy from age 40 to age 60. And I thought, ‘Yes, that is what I am going to do.’”In places where the water supply is compromised, a large proportion of people who contract cholera die without treatment. The advent of oral rehydration therapy in the 1960s — a simple, low-cost treatment — was a game-changer that saved millions of lives. But it discovery was thanks to a collaboration among people doing seemingly odd things in very different parts of the world.,“I arrived in Dhaka, East Pakistan [now Bangladesh] in 1965, when the prevailing theory was that the cholera toxin poisoned intestinal cells, preventing them from absorbing water back into circulation. That was thought to explain why people lost gallons of fluid in just a few hours, and why so many of them died,” said Sachar.As a newly commissioned public health officer, Sachar joined Robert Gordon, director of the Clinical Center of the National Institutes of Health (NIH), who was setting up a research laboratory with Navy scientist Robert Phillips. Gordon wanted to investigate the assumption that cholera toxins poisoned the sodium pump that keeps intestinal fluids in balance.“He said, ‘If the cholera toxin poisons the sodium pump, that should change the normal electric charge in the intestine. Why don’t you measure it?’”Phillips contacted his colleague Hans Ussing in Copenhagen, who had invented a device to measure electrical charge in tissues. At the time, biologists used the Ussing chamber to study the influences of chemical changes on the electrical charge across a frog skin.“The Ussing chamber was a good way to measure charge across a membrane, so Phillips said if you can figure it out in frog skin, maybe you can figure it out how to use in a living person with cholera. So, I packed up and went off to Copenhagen for a few months with my wife and baby, and learned how to use it.”Sachar mastered the device, then adapted the techniques he learned to measure potential across the intestinal wall in an intact human being. He headed back to Dhaka, imported the unwieldy equipment, set up the new system, and successfully measured electric charge in a human patient.,The accidental experiment“I came across research from the University of Sheffield. … They had found that if you added sugar to the infusion solution inside [rat] intestine, that would boost the electric potential, presumably by boosting active sodium transport. So I thought, if I’m measuring what I think I’m measuring here, then if we add sugar to the lumen it should raise the potential. So that’s what we did.”The team found a patient willing to let them try the new technique on his intestinal wall. They set up the device and measured the charge as the patient received a standard electrolyte solution. Then they added sugar to the solution, and saw an immediate change. The patient’s electric potential began to rise dramatically.“We made two discoveries: our measuring system was good, and the prevailing theory of cholera was wrong,” said Sachar. “The sodium transport system wasn’t poisoned — it responded just the way it was supposed to.” He said it was Norbert Hirschhorn, the lab’s chief of clinical research, who said, “That’s the therapy! We’ll rehydrate patients orally with the sugar, without IV!”Phillips and other team members opposed moving straight to treatment, because previous experiments along similar lines hadn’t worked. But Hirschhorn insisted it would work if the composition of salts and sugar was just right. The team decided to try an oral treatment, staying with the patients in shifts around the clock. The therapy worked.“That was the birth of oral rehydration therapy,” said Sachar. “Two years later, two other Public Health Service doctors, Richard Cash and David Nalin, took the treatment out into the field, to mothers and children in rural East Pakistan, and saved a lot of lives.“We couldn’t have proved it would work without having done those experiments in frog skin. But on the other side of the coin, I could still be tinkering away in a lab in Copenhagen, and those researchers could still be looking at rats in Sheffield, and it wouldn’t mean anything. We did something incredible because we took the science to where the disease was hitting people. It’s that combination of basic and applied research that makes the whole thing work,” said Sachar.Sachar’s research is credited with having already saved at least 50 million lives worldwide. This award is the first time the basic science behind the treatment has been formally recognized.Noel Rose, a fellow recipient of the award, was recognized for his exploratory research in the 1950s that changed our understanding of autoimmunity. “A lot of good comes from accidental experiments, where you’re looking for one thing and along the way make a discovery that changes the world,” he said.Rose’s early work at the University of Buffalo, funded by a cancer immunology grant, investigated a thyroid protein, thyroglobulin, by exploring how rabbits responded to similar proteins from other species. On a hunch, he tested whether a rabbit would respond to thyroglobulin taken from its own body. It did, producing not only antibodies to thyroglobulin in the serum, but severe inflammation of its own thyroid gland. This unexpected finding led to a revolution in the study of autoimmunity.“My boss, Ernest Witebsky, was sure that I was on the wrong track, because, ‘Everyone knows that’s impossible,’” said Rose. But after looking for every possible alternative explanation, Rose tested samples from patients with Hashimoto thyroiditis and showed that they, too, had antibodies to thyroglobulin.“Witebsky said, ‘My boy, you’ve done it!’” recalled Rose.Rose’s work led to the revelation that more than 80 diseases, including Type 1 diabetes and lupus, are related to an autoimmune response. Since that discovery, new diagnostic tools and treatments have become available, giving hope to millions of patients.“It’s not an easy time for young researchers, but I do encourage them,” said Rose. “Despite the problems they will encounter, this a career that just gives and gives. You have the privilege of doing work you love, sometimes discovering new things about the world we live in — that is a privilege very few people have.” Most transformative medicines originate in curiosity-driven science, evidence sayscenter_img For new medicines, turn to pioneerslast_img read more

January 18, 2021 | |Post a Comment

first_imgShare:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to email this to a friend (Opens in new window) Public Domain Pictures GERRY — New York State Police have released more information regarding the drowning death of a three-year-old boy in the Town of Gerry.Troopers said that at 4:40 p.m., Monday, they responded to a call for a missing child on Damon Hill Road.While patrols were in route to the area, the child was found unresponsive at the bottom of an above ground pool.Troopers and a Chautauqua County Sheriff’s Deputy attempted life-saving measures but were not successful. Police said the child was not wearing a life vest. His body was transported to the Erie County Medical Examiner’s Office for an autopsy.Sinclairville Fire Department and EMS assisted in this incident, which remains under investigation.last_img read more

December 31, 2020 | |Post a Comment

first_img FacebookTwitterLinkedInEmailPrint分享S&P Global Market Intelligence ($):Power plant owners with plans to retire the most coal-fired capacity in the next several years said they would not change course based on the Trump administration’s scaled-back replacement of the Obama-era Clean Power Plan.The Affordable Clean Energy, or ACE, rule was finalized June 19 and uses a narrower interpretation of the agency’s authority to regulate carbon dioxide emissions. Still, several plant operators with scheduled retirements of their coal-fired facilities have either publicly indicated or told S&P Global Market Intelligence those plans have not changed.Despite President Donald Trump’s campaign promises to revive the U.S. coal sector, domestic power producers have retired coal capacity at a fairly steady pace since 2014, even as the Clean Power Plan was stayed by the U.S. Supreme Court and later replaced completely. Moody’s said despite the rule requiring minimal investment from coal plant operators to comply, ACE would “not materially slow the nationwide transition away from coal due to the current low natural gas price environment,” an assessment that was shared by Fitch Ratings.“The new rule may result in a slower decline in coal-fired generation; however, it will not change the dynamics that have driven dramatic increases in both natural-gas fired and renewable generation,” Fitch Ratings wrote in a June email.While the largest amount of retirements in the last few years occurred in 2015 when 15.1 GW of coal-fired capacity came offline, the second-highest year for coal plant retirements was last year, when 13.5 GW was taken offline. Another 9.7 GW is scheduled to retire in 2019.While the economics of natural gas and renewable energy compared to coal are driving much of the shift, Duke Energy Corp. spells out that part of the issue is growing public concern about climate change. Duke Energy Indiana LLC’s integrated resource plan moves up the planned retirement of more than 4,100 MW of coal capacity by shutting down its Cayuga and Gibson plants by 2038.More ($): Coal plant operators stick to closure plans despite Trump’s changes to CO2 rules Utilities say new emission rules won’t change their coal plant retirement planslast_img read more

December 17, 2020 | |Post a Comment

first_imgThe Department of Justice (DOJ) announced this week that the U.S., in conjunction with international law enforcement authorities, disrupted a series of business email compromise (BEC) schemes that were designed to intercept and hijack wire transfers from businesses and individuals.As a result of “Operation reWired,” $3.7 million was seized and 281 arrests were made.“The Department of Justice has increased efforts in taking aggressive enforcement action against fraudsters who are targeting American citizens and their businesses in business email compromise schemes and other cyber-enabled financial crimes,” said Deputy Attorney General Jeffrey Rosen in a statement.“Through Operation reWired, we’re sending a clear message to the criminals who orchestrate these BEC schemes: We’ll keep coming after you, no matter where you are,” added FBI Director Christopher A. Wray.  “And to the public, we’ll keep doing whatever we can to protect you.  Reporting incidents of BEC and other internet-enabled crimes to the IC3 brings us one step closer to the perpetrators.” continue reading » ShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblrlast_img read more

December 16, 2020 | |Post a Comment

first_imgSign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York A West Hempstead attorney was arrested Monday for allegedly stealing more than $5.7 million from clients over a two-year span, Nassau County prosecutors said.David Frankel was charged with seven counts of grand larceny.Prosecutors said that the 50-year-old man withdrew funds from an escrow account containing money belonging to seven realty companies that he represented between 2012 and last year.Frankel allegedly used the money to fund his own unsuccessful investments and to make payments in unrelated real estate transactions, authorities said.Judge Darlene Harris set bail for Frankel at $300,000. He faces up to 25 years in prison, if convicted. He is due back in court Wednesday.last_img read more

November 20, 2020 | |Post a Comment

first_img‘Half doctor, half netballer’ are the words housed within Guscoth’s biography on Twitter, and she has always been open about how the two parts of her life complement each other and balance her.In Adelaide Thunderbirds’ announcement of her departure from Suncorp Super Netball (SSN), the defender shared the challenges she faced working in Australia.“Being a full-time athlete has huge perks but as imports we are so restricted with our visas as to what we can do outside of the sport, even in a voluntary role,” Guscoth told the Thunderbirds’ website.“Although we tried to explore options to allow me to do more medical work around training, it was becoming more difficult especially with COVID-19.“Given the ongoing pandemic, working in some capacity is something that I am keen to be able to do.”“I am very grateful to the Thunderbirds for the opportunity to play in SSN,” she continued. “It had never been something I thought that I would achieve.”In returning to Team Bath, Guscoth will be able to step back into a netball environment she s incredibly comfortable in and have the chance to develop her medical career too. Layla Guscoth is rejoining Team Bath as she moves back to England
Layla Guscoth is rejoining Team Bath as she moves back to England

November 18, 2020 | |Post a Comment

first_imgForten Group and the world’s leading integrated tourism group TUI, one of the previous partners owned by Karisma Hotels Adriatic (KHA), have reached an agreement whereby TUI takes over a 33,3 percent stake in Forten Group in the holding company that manages Hotels Kolocep, Hotels Zivogosce and Adriasense Zagreb. The total capacity of the three modern, decorated four-star hotels is 589 rooms. KHA had almost 350.000 overnight stays at its facilities last year, and guests were mostly from the UK, Germany, Scandinavia and France. The transaction will be formally concluded after the Competition Agency approves the KHA concentration to TUI. “As we have already pointed out, Forten’s group has a clear strategy of focusing on core business in retail, food and agriculture and overall a less complex grouping, which will allow us to achieve a better return in the future. Therefore, we were looking for the right partners to take over and improve our business in the tourism sector. As one of our partners in the ownership structure of KHA, TUI was a natural choice for the realization of this transaction, because in addition to the international tour operator activity of this group brought the largest number of guests to hotels and camps, it also knows the business operations of KHA and more importantly, it has an elaborate vision of the future for that business, and that is extremely important to usSaid James Pearson, CFO of Forten Group. Photo: TUI BLUE Adriatic Beach Resortlast_img read more

October 19, 2020 | |Post a Comment

first_imgHe highlighted the need for better data integration by standardizing the variables and systems for data input.But the national COVID-19 task force, tasked with announcing the data collected by the Health Ministry, said that it was using data that indicated where the patients were physically being treated.”The right [process] is to submit both NIK or KTP and domicile [information]. What is used is certainly the domicile data showing where patients are treated,” task force spokesperson Wiku Adisasmito told the Post.”If there’s no domicile data then it’s treated as if [a patient’s] residence is the same as their address on their KTP. We use KTP data – NIKs, names and addresses – to verify data so there won’t be duplicates.”Wiku said the ministry could be receiving incomplete data from provincial administrations. He said that the task force was working on improving interoperability between national and regional data so that there would not be any discrepancies.Achmad Yurianto, the ministry’s director general for disease control and prevention and former government spokesperson for COVID-19 affairs, insisted that the ministry’s data was collected from data submitted by provincial administrations.”If the provincial administrations have their own [data], please ask them why it isn’t the same as the [data they] gave to the central [government],” he told the Post on Thursday.This is not the first time that such discrepancies have come to light.In May, West Java Governor Ridwan Kamil told a roundtable discussion with foreign ambassadors that the numbers announced by the Health Ministry in daily press conferences, which no longer run now, did not match those reported by his regional administration.“For example, I reported 30 cases today; the central government put five in the report. I reported seven today, the central government reported 50,” he said on May 11.Airlangga University epidemiologist Laura Navika Yamani said that data discrepancies did not only exist between Central Java and the central government, but among many other regions, including between East Java and its capital, Surabaya. Laura said such discrepancies should have already been fixed given that the country was five months into the pandemic, and the fact that this problem persisted had shown a lack of coordination between the state and regions.”A gap of hundreds in data on fatalities should be questioned. Who are these 200 deceased people?” she said.With inaccurate data that did not reflect the reality of the pandemic in the country, it was difficult to predict how the situation would unfold, Laura said. As a result, the government would have a hard time coming up with the right policies, she added.”The public will also be confused by the data. Data discrepancies will cultivate distrust toward the government, making it harder [to implement] policies set forth by the government,” she said.She urged the government to improve its method of tracking cases before drawing any conclusions and making announcements to the public.The COVID-19 task force said on Aug. 2 that there had been a 28 percent decline in deaths from two weeks prior, with Bengkulu having the highest fatality rate at 8.09 percent, followed by East Java with 7.74 percent and Central Java with 6.73 percent.Topics : Data discrepancies have continued to be a problem for Indonesia five months since it announced its first COVID-19 cases, prompting concerns about outdated data and declining public trust in the government.Central Java, for instance, recorded on its website 11,423 total confirmed cases, with 3,529 active cases and 1,049 deaths as of 12 p.m. of Tuesday. However, according to the central government’s tally, Central Java’s cases stood at 10,765, with 3,888 active cases and 731 deaths as of Tuesday.There is a 318-figure gap between the reported fatalities and a 658-figure gap between the confirmed cases.The Central Java administration updates its data at 12 p.m. every day – the same cut-off time for daily data collection by the Health Ministry.Using data from the Central Java administration, the case fatality rate stands at 9.2 percent, yet with the central government’s tally, the rate significantly drops to 6.8 percent.Central Java Health Agency head Yulianto Prabowo said the differences were to be expected because there was no “bridge” between the information systems of provinces and the central government.He suspected that the reason for this was the difference in methods used to input data on patient domicile, with some cases recorded based on the patient’s location of residence, while other cases are based on a patient’s registered address according to their citizenship identification number (NIK) or ID card (KTP). As a result, a patient living in Central Java, for example, could have their data recorded in a different province.”Central Java data [is] based on domicile, central [government] data [is] based on the NIK,” Yulianto told The Jakarta Post on Sunday.”We actually send complete data based on domicile and on the NIK [to the central government], but the provincial [administration] tends to use the domicile data for [our] epidemiological purposes and [COVID-19] response.”Yulianto said that before the Health Ministry started recording data using the All Record TC-19 system, COVID-19 data was input into the Bersatu Lawan Covid (BLC) system, meaning there could be cases in which “data from the old system wasn’t brought into the new one”.last_img read more

September 29, 2020 | |Post a Comment

first_imgThe new fund – named Employees’ Fund for Residual Holiday Funds (Lønmodtagernes Fond for Tilgodehavende Feriemidler) – will manage the cash equivalent of an extra 12 months’ worth of holiday entitlements, which are being granted to existing employees in Denmark as a result of bringing its legislation in line with EU law.“We have some ideas ourselves but we also want to be very open and listen to thoughts and inspiration from a lot of sources”Charlotte Mark, LD“We are now in the phase where we are collecting inspiration, and we are trying to discuss with different external business partners and others, how should we actually do this, how should we set this up,” Mark said.“At the moment we have just posed a lot of questions, throwing the idea up in the air and having a lot of internal discussions.”As part of this, Mark and the team are going on tours to visit different asset managers and thought leaders with different perspectives, she said. Credit: LDLD’s office in Frederiksberg, DenmarkWhile LD currently invests purely in liquid equities and bonds – because as a declining fund with a high average member age it needs to be liquid – its management may consider adding less liquid assets to the new holiday fund.The new fund could include more alternatives, and it could include asset types that LD has not been investing in for a while, Mark said.Given that the new fund may bring in up to DKK85bn of assets to manage, is LD considering doing some investment in-house in the future?“Potentially it is something we will have to consider. But I don’t expect that we will build up a big staff internally. I think we might add a few resources to the team, but we will certainly continue using external managers,” she said.See also: LD gains a new lease of life, from IPE’s October edition Charlotte Mark, CFO, LD“We have some ideas ourselves of course, but we also want to be very open and listen to thoughts and inspiration from a lot of sources,” the CFO added. “At the same time we need to do some more analysis of the fund itself because there are a lot of unknowns.”How much will LD run?Perhaps the biggest of these unknown factors is how much money LD will be managing in the new fund.According to the government agreement about the management of the extra holiday entitlements, employers will be given the freedom to choose whether they put money they owe staff into the fund managed by LD, or whether they keep that liquidity and take out a loan with LD instead, servicing that borrowing at the rate of wage inflation.At the latest, companies must pay the money into LD when individuals retire, but it is a feature of the holiday fund legislation that firms can choose to pay at anytime before that.“We need to do some more analysis there because obviously the total fund will deliver a mix of this employer loan, which will give a return of wage inflation, and the return of the pool that LD will invest in capital market assets,” said Mark. “We have to look at the total fund and optimise. But how big a part of the total fund will consist of the employer loans initially and how this develops over time is an unknown.”While the total fund size could be as much as DKK85bn, LD does know at least that it will receive close to DKK10bn in the first year of the fund’s operation, because this is money that will already have been paid into existing vacation funds by employers during 2019.“We have to try to model employer behaviour, or at least work with some different scenarios, different possible pool sizes, and then have some different approaches,” Mark explained.“We have some theories. For instance, if you have turnover in your staff it may be too high an administrative burden to hold onto liquidity for people not working in your company anymore, so when companies have staff turnover, it is likely that they will choose to pay in for these employees.“It could also be the case that some smaller companies will find it too much of an administrative burden in their annual report and accounting, and they might choose to pay in, but obviously it also depends on how tight your liquidity is.”New asset classes being consideredWith the existing structure LD already has in the form of its investment of externally-managed “building blocks”, Mark said LD was ready to invest from day one.“What we have to decide is if we want to add different asset classes and different building blocks from the existing ones,” she said.center_img Having received the parliamentary go-ahead to manage Denmark’s new holiday fund, the small management team of Lønmodtagernes Dyrtidsfond (LD) has started work on designing the set-up for the new fund which could see a tripling of its assets under management.Charlotte Mark, CFO of LD, which currently manages DKK42.8bn (€5.7bn) pension fund, told IPE in an interview: “We are just at the dawn of thinking about how things should be.”LD was created to run a fund investing one-off frozen cost-of-living allowances granted to Danish employees at the end of the 1970s. There have been no new inflows since that original capital contribution from the government, so the fund has been gradually shrinking, despite investment returns and many members keeping their money invested with LD beyond retirement age.With its new mandate, LD seems set to continue for the next four decades.last_img read more